Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitatin...

Altered Distribution of Phospholipase C-’yl in Benign Hyperproliferative Epidermal Diseases’

Phospholipase C-yl (PLC-yl) is a well characterized substrate for the epidermal growth factor receptor tyrosine kinase and has been implicated in the intracellular biochemical signaling cascade which occurs following stimulation of cells with epidermal growth factor. The in vivo localization of PLC-’yl was examined by immunohistochemistry in sections of normal human skin and in skin sections fr...

Basics of Molecular Biology

We begin with a review of the basic molecules responsible for the functioning of all organisms’ cells. Much of the material here comes from the introductory textbooks by Drlica [4], Lewin [7], and Watson et al. [10]. Good short primers have been written by Hunter [6] and Brāzma et al. [2]. What sorts of molecules perform the required functions of the cells of organisms? Cells have a basic tensi...

Skin and Neck Cancer following Radiation Therapy for Benign Diseases.

Sixty-one cases of radiation-induced cancer were collected from selected big hospitals in Japan during 1961 and 1962. Of 61, 54 were cancer of skin or neck including the thyroid gland. All these cancers were developed in the area previously irradiated for treatment of benign diseases over throe years ago. The rate of male to female was approximately the same as that of natural cancers. Radiatio...

Equine Endocrine Diseases: The Basics